Sievers H H, Lange P E, Regensburger D, Yankah C A, Onnasch D G, Bürsch J, Heintzen P H, Bernhard A
J Thorac Cardiovasc Surg. 1983 Nov;86(5):777-83.
Correction of right ventricular outflow tract obstruction remains a challenge to cardiovascular surgeons. In order to relieve this obstruction and at the same time prevent or minimize pulmonary insufficiency, we inserted a cusp-bearing transannular patch (monocusp) in 14 patients. To test this objective, we restudied 13 of these patients 0.5 to 4 months postoperatively, including quantifying pulmonary insufficiency using an accurate videodensitometric method. In all patients a degree of pulmonary insufficiency ranging from 8% to 46% of total stroke volume (mean 22.7 +/- 10.6%) was measured, and in all but one a residual right ventricular outflow pressure gradient of 2 to 22 mm Hg (mean 10 +/- 7 mm Hg) was measured. There was an inverse relation between the degree of pulmonary insufficiency and both the pressure gradient (r = -0.89) and the ratio of the pulmonary valve ring diameter to monocusp depth (r = -0.67). An ideal reconstruction of the right ventricular outflow tract obstruction, without any postoperative pulmonary insufficiency and stenosis, was not achieved by the implantation of a monocusp in the described fashion. The postoperative results were acceptable in only a few patients. A reduction of pulmonary insufficiency seems to be associated with a small residual pressure gradient as well as a relatively small cusp size. Additional studies are necessary to further improve surgical correction of right ventricular outflow tract obstruction with reproducible and predictable results.
右心室流出道梗阻的矫治仍然是心血管外科医生面临的一项挑战。为了缓解这种梗阻并同时预防或尽量减少肺动脉瓣关闭不全,我们为14例患者植入了带瓣叶的跨环补片(单瓣叶)。为验证这一目标,我们在术后0.5至4个月对其中13例患者进行了再次研究,包括使用精确的视频密度测定法对肺动脉瓣关闭不全进行量化。在所有患者中,测得的肺动脉瓣关闭不全程度占总心搏量的8%至46%(平均22.7±10.6%),除1例患者外,所有患者的右心室流出道压力阶差残余值为2至22毫米汞柱(平均10±7毫米汞柱)。肺动脉瓣关闭不全程度与压力阶差(r = -0.89)以及肺动脉瓣环直径与单瓣叶深度之比(r = -0.67)之间呈负相关。采用上述方式植入单瓣叶未能实现右心室流出道梗阻的理想重建,且无任何术后肺动脉瓣关闭不全和狭窄。仅少数患者的术后结果可接受。肺动脉瓣关闭不全的减轻似乎与较小的残余压力阶差以及相对较小的瓣叶尺寸有关。需要进一步开展研究,以进一步改善右心室流出道梗阻的外科矫治效果,使其具有可重复性和可预测性。