Sasu B I, Liashko V N
Biull Eksp Biol Med. 1983 Nov;96(11):123-5.
Glucocorticoid (GC) receptors were studied in intact lymphocytes from 11 donors. GC binding parameters were found to be highly reproducible in repeated experiments with lymphocytes. It was shown that GC receptors in donors' lymphocytes could be distributed into two different classes similarly to the pattern seen in skin fibroblasts. Human lymphocytes are an adequate object for studying genetically determined variability of GC receptors and its clinical importance.
对11名捐赠者的完整淋巴细胞中的糖皮质激素(GC)受体进行了研究。在对淋巴细胞的重复实验中发现,GC结合参数具有高度可重复性。结果表明,捐赠者淋巴细胞中的GC受体可分为两类,类似于在皮肤成纤维细胞中观察到的模式。人类淋巴细胞是研究GC受体的遗传决定变异性及其临床重要性的合适对象。