Mimura T, Kohda I, Maeda K, Iwai M, Sasaki Y, Aonuma S, Momose T
J Pharmacobiodyn. 1983 Aug;6(8):527-37. doi: 10.1248/bpb1978.6.527.
Among various unsaturated fatty acids which were examined in this experiment, trans-2-tridecenoic acid was found to be a potent inhibitor on gastric secretion in rats (i.p. or i.d.). Therefore, the effects of trans-2-tridecenoic acid on several experimental ulcerations in rats were examined. At the dose of 10 mg/kg, trans-2-tridecenoic acid significantly decreased the ulcer index in pylorus-ligated rats; aspirin-, phenylbutazone-, histamine- and stress-induced ulcerations were also significantly inhibited at the dose of 25 mg/kg. Finally, effects of trans-2-tridecenoic acid on hexosamine and sialic acid contents in the gastric mucous were examined. In intact or phenylbutazone-induced ulcerated rats, trans-2-tridecenoic acid increased the sialic acid levels in the gastric mucous at the dose of 25 mg/kg. The decreased hexosamine content in the gastric mucous by phenylbutazone treatment was recovered by the administration of trans-2-tridecenoic acid.
在本实验检测的各种不饱和脂肪酸中，反式-2-十三碳烯酸被发现是大鼠胃分泌的有效抑制剂（腹腔注射或皮内注射）。因此，研究了反式-2-十三碳烯酸对大鼠几种实验性溃疡的影响。在10mg/kg剂量下，反式-2-十三碳烯酸显著降低幽门结扎大鼠的溃疡指数；在25mg/kg剂量下，阿司匹林、保泰松、组胺和应激诱导的溃疡也受到显著抑制。最后，检测了反式-2-十三碳烯酸对胃黏液中氨基己糖和唾液酸含量的影响。在完整或保泰松诱导溃疡的大鼠中，25mg/kg剂量的反式-2-十三碳烯酸可提高胃黏液中的唾液酸水平。保泰松处理导致的胃黏液中氨基己糖含量降低，通过给予反式-2-十三碳烯酸得以恢复。
