凝血因子IX浓缩物的血栓形成性：体外和体内（兔）研究

Thrombogenicity of factor IX concentrates: in vitro and in vivo (rabbit) studies.

作者信息

Cash J D, Owens R, Dalton R G, Prescott R J

出版信息

Vox Sang. 1978 Jul-Aug;35(1-2):105-10. doi: 10.1111/j.1423-0410.1978.tb02907.x.

DOI:10.1111/j.1423-0410.1978.tb02907.x

Abstract

The reproducibility and correlation between the NAPTT, TGt50 in (vitro) tests and the Wessler (rabbit) stasis thrombus (in vivo) model have been studied using 10 different factor IX concentrates. The TGt50 test was more reproducible than the NAPTT and the overall reproducibility of the rabbit model was poor. The low reproducibility of the rabbit model appeared to be largely confined to those factor IX concentrates which showed a poor correlation between the NAPTT and TGt50 results. The TGt50 test emerged as the in vitro test which correlated most closely with the in vivo (rabbit) test. It is concluded that the NAPTT and TGt50 test are measuring different thrombogenic moieties in factor IX concentrates and that further studies are required to elucidate this phenomenon.

摘要

使用10种不同的凝血因子IX浓缩剂，研究了活化部分凝血活酶时间（APTT）、（体外）检测中的凝血酶生成时间（TGt50）与韦氏勒（兔）静脉淤滞血栓（体内）模型之间的可重复性和相关性。TGt50检测比APTT具有更高的可重复性，而兔模型的整体可重复性较差。兔模型的低可重复性似乎主要局限于那些在APTT和TGt50结果之间显示出较差相关性的凝血因子IX浓缩剂。TGt50检测成为与体内（兔）检测相关性最密切的体外检测方法。得出的结论是，APTT和TGt50检测正在测量凝血因子IX浓缩剂中不同的致血栓形成部分，需要进一步研究来阐明这一现象。