SL76002 - 对长期服用氟哌啶醇的动物体内γ-氨基丁酸和多巴胺的影响。

SL76002 - effect on gamma-aminobutyric acid and dopamine in animals treated chronically with haloperidol.

作者信息

Rastogi S K, Rastogi R B, Singhal R L, Lapierre Y D

出版信息

Neuropsychobiology. 1983;9(4):211-4. doi: 10.1159/000117966.

Abstract

Daily haloperidol injection at the dose of 5 mg/kg for 34 days did not change the levels of dopamine in the corpus striatum, frontal cortex, and midbrain of rats. However, the gamma-aminobutyric acid (GABA) level was increased by 27% in the corpus striatum. Haloperidol withdrawal for 4 days after 30-day treatment increased GABA levels of the corpus striatum and the frontal cortex to 140 and 125%, respectively, of control values. GABA, by its inhibitory actions, depleted dopamine level in the corpus striatum and frontal cortex by 17 and 29%, respectively. Administration of SL76002, a new GABA agonist, for 4 days at the dose of 400 mg/kg i.p. to haloperidol-withdrawn rats increased GABA levels in striatum by 23% of control values. The dopamine levels were also decreased significantly in the frontal cortex and corpus striatum. Our data demonstrate that SL76002, by altering the GABA levels, probably influences DA functioning in the corpus striatum, a region responsible for involuntary movements.

摘要

以5毫克/千克的剂量每日注射氟哌啶醇，持续34天，并未改变大鼠纹状体、额叶皮质和中脑中多巴胺的水平。然而，纹状体中的γ-氨基丁酸（GABA）水平升高了27%。在30天的治疗后停药4天，纹状体和额叶皮质中的GABA水平分别升至对照值的140%和125%。GABA通过其抑制作用，使纹状体和额叶皮质中的多巴胺水平分别降低了17%和29%。对停用氟哌啶醇的大鼠腹腔注射剂量为400毫克/千克的新型GABA激动剂SL76002，持续4天，使纹状体中的GABA水平升高至对照值的23%。额叶皮质和纹状体中的多巴胺水平也显著降低。我们的数据表明，SL76002通过改变GABA水平，可能影响纹状体中多巴胺的功能，而纹状体是负责非自主运动的区域。