Chorváthová V, Ondreicka R
Physiol Bohemoslov. 1983;32(5):466-75.
The authors studied acute changes in the fatty acid composition of the tissues of streptozotocin-diabetic rats. They found that streptozotocin diabetes led to changes in the total lipids fatty acid spectrum in serum and in tissues (liver, adipose tissue, renal cortex diaphragm). After only 7 days' diabetes there was an increase in the percentual proportion of saturated fatty acids and a decrease in the amount of polyene fatty acids in the serum and in all the above tissue of diabetic animals. Palmitic acid (16:0) participated in the increase in the proportion of saturated fatty acids in all the given tissues, while stearic acid (18:0) played a role in the increase in the renal cortex and the serum. Among the monoene acids, there was a drop in the proportion of palmitoleic acid (16:1) in the adipose tissue and serum and in the amount of oleic acid (18:1) in the renal cortex, liver and muscle. Linoleic acid (18:2) played a role in the decrease in the proportion of polyene acids in all the given tissues and the serum, while arachidonic acid (20:4) was involved in the drop in the renal cortex, liver and muscle. The results show that diabetes leads to changes in the fatty acid composition of the renal cortex and muscle, as well as of the liver and adipose tissue. At present it is not yet clear whether there is an absolute decrease in the proportion of essential fatty acids, or whether diabetes is characterized by an increase in the amount of lipids in both serum and tissues.
作者研究了链脲佐菌素诱导的糖尿病大鼠组织中脂肪酸组成的急性变化。他们发现链脲佐菌素诱导的糖尿病导致血清和组织（肝脏、脂肪组织、肾皮质、膈肌）中总脂质脂肪酸谱发生变化。糖尿病仅7天后，糖尿病动物血清及上述所有组织中饱和脂肪酸的百分比增加，多烯脂肪酸含量降低。棕榈酸（16:0）参与了所有给定组织中饱和脂肪酸比例的增加，而硬脂酸（18:0）在肾皮质和血清的增加中起作用。在单烯酸中，脂肪组织和血清中棕榈油酸（16:1）的比例下降，肾皮质、肝脏和肌肉中油酸（18:1）的含量下降。亚油酸（18:2）在所有给定组织和血清中多烯酸比例的降低中起作用，而花生四烯酸（20:4）参与了肾皮质、肝脏和肌肉中的下降。结果表明，糖尿病导致肾皮质、肌肉以及肝脏和脂肪组织的脂肪酸组成发生变化。目前尚不清楚必需脂肪酸的比例是否绝对下降，或者糖尿病的特征是否是血清和组织中脂质含量增加。
