Cote I L, Bowers A, Jaeger R J
Res Commun Chem Pathol Pharmacol. 1983 Oct;42(1):169-72.
Pretreatment by inhalation with sublethal concentrations of acrylonitrile protects rats from subsequent, normally lethal, ACN exposures. However, inhalation-induced tolerance to ACN does not protect against subsequent poisoning by cyanide. Metabolic liberation of cyanide has been suggested to be responsible for the toxicity of ACN. Protection against ACN toxicity is not provided by pretreatment with compounds which have structural similarity to ACN, i.e. acrylamide or ethylene, nor by cyanide per se. Enzyme induction with Aroclor 1254 also does not protect against ACN toxicity. The latter data suggest that the tolerance resulting from ACN pretreatment is not the result of enzyme induction and the basis for the protective effect of ACN inhalation pretreatment remains unclear.
用亚致死浓度的丙烯腈进行吸入预处理可保护大鼠免受随后通常致命的丙烯腈暴露。然而，吸入诱导的对丙烯腈的耐受性并不能预防随后的氰化物中毒。有人提出氰化物的代谢释放是丙烯腈毒性的原因。与丙烯腈结构相似的化合物（即丙烯酰胺或乙烯）预处理以及氰化物本身预处理均不能预防丙烯腈毒性。用多氯联苯混合物1254进行酶诱导也不能预防丙烯腈毒性。后一组数据表明，丙烯腈预处理产生的耐受性不是酶诱导的结果，吸入丙烯腈预处理产生保护作用的基础仍不清楚。
