氨磺酸盐作为一种局部应用的化学物质用于预防小鼠曼氏血吸虫感染。

Amoscanate as a topically applied chemical for prophylaxis against Schistosoma mansoni infections in mice.

作者信息

Greene L K, Grenan M M, Davidson D E, Jones D H, Shedd T R

出版信息

Am J Trop Med Hyg. 1983 Nov;32(6):1356-63. doi: 10.4269/ajtmh.1983.32.1356.

DOI:10.4269/ajtmh.1983.32.1356

Abstract

Amoscanate (0.1% w/v) in methanol solution applied to skin by tail immersion 1 day prior to cercarial exposure provided mice with better than 90% protection against mature Schistosoma mansoni infections. Cercariae penetrated and schistosomula migrated from treated skins as readily as in control skins. Lung incubation assays, however, indicated that day 7 lung worm burdens were only about half those of control values. By day 20, worm burdens were reduced further to approximately 15% of those for control mice. The delayed prophylactic activity was apparently not due to percutaneously absorbed compound. Wipe application of amoscanate to the skin was nearly as effective as immersion.

摘要

在尾蚴暴露前1天，通过尾部浸入法将甲醇溶液中的硝硫氰胺（0.1% w/v）施用于皮肤，可使小鼠对曼氏血吸虫成熟感染的保护率超过90%。尾蚴穿透皮肤以及童虫从处理过的皮肤中迁移的情况与对照皮肤一样容易。然而，肺部孵育试验表明，第7天肺部的虫负荷仅约为对照值的一半。到第20天，虫负荷进一步降低至对照小鼠的约15%。这种延迟的预防活性显然不是由于经皮吸收的化合物所致。将硝硫氰胺擦拭在皮肤上的效果几乎与浸入法一样有效。