Vadlamani N L, Pontani R B, Misra A L
Arch Int Pharmacodyn Ther. 1983 Sep;265(1):4-12.
Disposition of [3H] phencyclidine (5 mg kg-1 i.p.) in brain, liver and plasma of rats treated chronically with 0.9% saline or nicotine (1 mg kg-1 s.c. twice a day for 11 days) was studied using a method possessing high sensitivity and specificity for PCP. No significant differences were observed in the values of PCP in plasma and tissues and in brain or liver to plasma PCP concentration ratios in the 2 groups 0.5, 1, 2 hr after [3H] PCP injection. With the exception of the value of PCP metabolites in plasma at 0.5 hr, the PCP metabolites concentrations were also not significantly different in the 2 groups. Data suggested that chronic nicotine pretreatment of rats did not affect the disposition of PCP and the potentiation of PCP-induced locomotor stimulant effects by nicotine possibly involves the additive pharmacodynamic interaction of 2 compounds at the level of the central nervous system.
采用一种对苯环己哌啶（PCP）具有高灵敏度和特异性的方法，研究了用0.9%生理盐水或尼古丁（1mg/kg皮下注射，每天两次，共11天）长期处理的大鼠脑、肝和血浆中[3H]苯环己哌啶（5mg/kg腹腔注射）的处置情况。在注射[3H]PCP后0.5、1、2小时，两组大鼠血浆和组织中的PCP值以及脑或肝与血浆PCP浓度比值均未观察到显著差异。除了0.5小时时血浆中PCP代谢物的值外，两组的PCP代谢物浓度也没有显著差异。数据表明，大鼠尼古丁预处理对PCP的处置没有影响，尼古丁对PCP诱导的运动兴奋作用的增强可能涉及两种化合物在中枢神经系统水平的相加药效学相互作用。
