作为慢性肺病预测指标的肺结构生化改变
Biochemical alterations of lung structure as predictors of chronic lung disease.
作者信息
Last J A
出版信息
Environ Health Perspect. 1983 Oct;52:159-63. doi: 10.1289/ehp.8352159.
Abstract
This presentation reports on newer animal models and techniques that we and others have developed. These models attempt to predict in a reasonable experimental time frame the occurrence of structural changes in the lungs that are the basis of various chronic diseases. Since the major chronic diseases of the lung parenchyma involving what we think of as well-understood structural changes are pulmonary fibrosis and emphysema, I will discuss in detail ways of looking at effects of air pollutants on lung collagen and lung elastin metabolism.
摘要
本报告介绍了我们及其他研究人员所开发的更新型动物模型和技术。这些模型试图在合理的实验时间范围内预测肺部结构变化的发生情况，而这些结构变化是各种慢性疾病的基础。由于肺实质的主要慢性疾病涉及我们认为已充分了解的结构变化，即肺纤维化和肺气肿，因此我将详细讨论研究空气污染物对肺胶原蛋白和肺弹性蛋白代谢影响的方法。
相似文献
1
Biochemical alterations of lung structure as predictors of chronic lung disease.作为慢性肺病预测指标的肺结构生化改变
Environ Health Perspect. 1983 Oct;52:159-63. doi: 10.1289/ehp.8352159.
2
Ozone-induced alterations in collagen metabolism of monkey lungs: use of biopsy-obtained lung tissue.臭氧诱导的猴肺胶原蛋白代谢改变：活检获取的肺组织的应用
Toxicol Appl Pharmacol. 1981 Sep 30;60(3):579-85. doi: 10.1016/0041-008x(81)90345-8.
3
Long-term consequences of exposure to ozone. I. Lung collagen content.
Toxicol Appl Pharmacol. 1984 Jan;72(1):111-8. doi: 10.1016/0041-008x(84)90254-0.
4
Collagen biosynthesis.胶原蛋白生物合成
Environ Health Perspect. 1984 Apr;55:169-77. doi: 10.1289/ehp.8455169.
5
Pulmonary fibrosis in experimental acute respiratory disease.实验性急性呼吸道疾病中的肺纤维化
Am Rev Respir Dis. 1981 Jan;123(1):58-63. doi: 10.1164/arrd.1981.123.1.58.
6
The effects of chronic ozone exposure on pulmonary collagen content and collagen synthesis in rats.
J Appl Toxicol. 1986 Apr;6(2):87-90. doi: 10.1002/jat.2550060204.
7
[Lung lesions induced by oxygen or ozone in rats].
Pathol Biol (Paris). 1974 Jan;22(1):89-98.
8
Ozone-induced acute pulmonary fibrosis in rats. Prevention of increased rates of collagen synthesis by methylprednisolone.臭氧诱导的大鼠急性肺纤维化。甲基强的松龙对胶原合成速率增加的预防作用。
Am Rev Respir Dis. 1981 Jan;123(1):47-52. doi: 10.1164/arrd.1981.123.1.47.
9
Ozone-induced alterations in collagen metabolism of rat lungs.
Toxicol Appl Pharmacol. 1979 Nov;51(2):247-58. doi: 10.1016/0041-008x(79)90467-8.
10
Changes in the collagen pathway in fibrosis.纤维化过程中胶原蛋白途径的变化。
Fundam Appl Toxicol. 1985 Apr;5(2):210-8. doi: 10.1016/0272-0590(85)90069-7.
本文引用的文献
1
Ozone-induced alterations in collagen metabolism of rat lungs II. Long-term exposures.
Toxicol Appl Pharmacol. 1980 Aug;55(1):108-14. doi: 10.1016/0041-008x(80)90226-4.
2
Pulmonary effects of prolonged ozone insult in rats. Morphometric evaluation of the central acinus.大鼠长期臭氧损伤的肺部效应。中央腺泡的形态计量学评估。
Lab Invest. 1980 Aug;43(2):108-15.
3
Elastin turnover in murine lung after repeated ozone exposure.
Toxicol Appl Pharmacol. 1981 Apr;58(2):203-10. doi: 10.1016/0041-008x(81)90424-5.
4
Bleomycin-induced pulmonary fibrosis: correlation of biochemical, physiological, and histological changes.博来霉素诱导的肺纤维化：生化、生理及组织学变化的相关性
Toxicol Appl Pharmacol. 1981 Sep 15;60(2):360-7. doi: 10.1016/0041-008x(91)90239-b.
5
Pulmonary fibrosis in experimental acute respiratory disease.实验性急性呼吸道疾病中的肺纤维化
Am Rev Respir Dis. 1981 Jan;123(1):58-63. doi: 10.1164/arrd.1981.123.1.58.
6
Lung statics and connective tissues after penicillamine in bleomycin-treated hamsters.青霉胺对博来霉素处理的仓鼠肺静态和结缔组织的影响
J Appl Physiol Respir Environ Exerc Physiol. 1980 Dec;49(6):1083-90. doi: 10.1152/jappl.1980.49.6.1083.
7
Effect of chronic ozone exposure on lung elasticity in young rats.慢性臭氧暴露对幼鼠肺弹性的影响。
J Appl Physiol. 1974 Jul;37(1):92-6. doi: 10.1152/jappl.1974.37.1.92.
8
Lung collagen composition and synthesis. Characterization and changes with age.肺胶原成分与合成。特征及随年龄的变化。
J Biol Chem. 1974 May 10;249(9):2674-83.
9
Role of histamine and related substances in development of tolerance to edemagenic gases.
Toxicol Appl Pharmacol. 1965 Sep;7(5):756-66. doi: 10.1016/0041-008x(65)90134-1.
10
Ozone exposure, adaptation, and changes in lung elasticity.臭氧暴露、适应性及肺弹性的变化
Environ Res. 1979 Aug;19(2):449-59. doi: 10.1016/0013-9351(79)90070-7.
Zotero 插件