蓖麻毒素对小鼠植入前胚胎发育的抑制作用。
Inhibitory effect of ricin on the development of preimplantation mouse embryos.
作者信息
Storeng R, Jonsen J
出版信息
J Toxicol Environ Health. 1983 Aug-Sep;12(2-3):193-202. doi: 10.1080/15287398309530418.
PMID:6655729
Abstract
Preimplantation mouse embryos were exposed to ricin, a plant toxin, in vitro and in vivo. The effect was evaluated by morphological observations of the exposed embryos as well as by means of protein synthesis. Ricin was highly toxic to the preimplantation mouse embryo in vitro, the effect being greater on the 2-cell than on the 4-8 cell stage. Intraperitoneal injection of ricin induced a small number of fetuses with exencephaly.
摘要
将植入前的小鼠胚胎在体外和体内暴露于蓖麻毒素（一种植物毒素）。通过对暴露胚胎的形态学观察以及蛋白质合成方法来评估其效果。蓖麻毒素在体外对植入前的小鼠胚胎具有高度毒性，对2细胞期胚胎的影响大于对4 - 8细胞期胚胎的影响。腹腔注射蓖麻毒素会导致少数胎儿出现无脑畸形。
相似文献
1
Inhibitory effect of ricin on the development of preimplantation mouse embryos.蓖麻毒素对小鼠植入前胚胎发育的抑制作用。
J Toxicol Environ Health. 1983 Aug-Sep;12(2-3):193-202. doi: 10.1080/15287398309530418.
2
Effect of Shigella toxin on preimplantation mouse embryos in vitro.志贺毒素对体外培养的小鼠植入前胚胎的影响。
Teratology. 1986 Apr;33(2):243-6. doi: 10.1002/tera.1420330212.
3
Effects of paraquat on development of preimplantation embryos in vivo and in vitro.百草枯对体内和体外着床前胚胎发育的影响。
Reprod Toxicol. 2005 Jul-Aug;20(2):239-46. doi: 10.1016/j.reprotox.2005.03.006.
4
Effect of tumour necrosis factor-alpha (TNF-alpha) on protein synthesis by mouse preimplantation stage embryos in vitro.肿瘤坏死因子-α（TNF-α）对体外培养的小鼠植入前阶段胚胎蛋白质合成的影响。
Indian J Physiol Pharmacol. 2005 Apr;49(2):139-47.
5
[The protective effect of stem cell factor (SCF) on in vitro development of preimplantation mouse embryos].[干细胞因子（SCF）对小鼠植入前胚胎体外发育的保护作用]
Ann Acad Med Stetin. 2005;51(1):83-93.
6
Recent progress in teratology. A survey of methods for the study of drug actions during the preimplantation period.畸形学的最新进展。着床前期药物作用研究方法综述。
Arzneimittelforschung. 1978;28(10):1733-42.
7
Sensitivity of preimplantation mouse embryos to abrin.植入前小鼠胚胎对相思子毒素的敏感性。
Acta Pharmacol Toxicol (Copenh). 1985 Nov;57(5):328-35. doi: 10.1111/j.1600-0773.1985.tb00053.x.
8
Effect of sodium and betaine in culture media on development and relative rates of protein synthesis in preimplantation mouse embryos in vitro.
Mol Reprod Dev. 1993 May;35(1):24-8. doi: 10.1002/mrd.1080350105.
9
The effects of in vivo administration of teratogenic doses of vitamin A during the preimplantation period in the mouse.在小鼠植入前期给予致畸剂量维生素A进行体内给药的影响。
Teratology. 1988 Jan;37(1):7-11. doi: 10.1002/tera.1420370103.
10
Mouse preimplantation embryo development in vitro: effect of sodium concentration in culture media on RNA synthesis and accumulation and gene expression.小鼠植入前胚胎的体外发育：培养基中钠浓度对RNA合成、积累及基因表达的影响
Mol Reprod Dev. 1994 Jun;38(2):131-41. doi: 10.1002/mrd.1080380203.
Zotero 插件