纳洛酮不能拮抗用氟烷麻醉的大鼠的翻正反射。

Naloxone fails to antagonize the righting response in rats anesthetized with halothane.

作者信息

Bennett P B

出版信息

Anesthesiology. 1978 Jul;49(1):9-11. doi: 10.1097/00000542-197807000-00004.

DOI:10.1097/00000542-197807000-00004

Abstract

The righting responses of 75 Wistar rats during exposure to halothane, 0.5 per cent, 10 min after subcutaneous injection of naloxone, 10 or 20 mg/kg, or saline solution were examined. There was no difference in recoveries of the righting responses among the three groups. It is concluded that naloxone does not antagonize the loss of righting response produced by halothane anesthesia in the rat.

摘要

研究了75只Wistar大鼠在皮下注射10或20mg/kg纳洛酮或生理盐水溶液10分钟后，暴露于0.5%氟烷10分钟期间的翻正反射。三组之间翻正反射的恢复情况没有差异。结论是纳洛酮不能拮抗氟烷麻醉所致大鼠翻正反射的丧失。