You B, Lardenet F, Schooneman F, Grillat J P
Rev Med Interne. 1983 Sep;4(3):231-5. doi: 10.1016/s0248-8663(83)80021-6.
Seven patients with Behcet's syndrome were given plasma exchanges (PE). They all had severe forms, essentially ocular, which had been previously treated by steroids and/or immunosuppressors for a number of years without effect on the course of the disease. The PE was associated with classical medical therapy in all cases. Four patients had daily PE on three consecutive days. Poor results were obtained in all cases with this technique. Five patients had monthly PE and a clinical improvement was observed in 4 cases, usually with a reduction in the number of exacerbations. All therapy failed in one patient who continued to have severe exacerbations. From this short series, PE would appear to be useful in chronic forms of the disease incompletely controlled by medical therapy. In these cases, PE should be repeated. However, a longer follow-up is necessary to confirm these results.
七名白塞病患者接受了血浆置换(PE)治疗。他们均患有严重类型的白塞病,主要为眼部病变,此前曾使用类固醇和/或免疫抑制剂治疗数年,但对疾病进程并无效果。所有病例的血浆置换均与传统药物治疗相结合。四名患者连续三天每日进行血浆置换。采用该技术的所有病例效果均不佳。五名患者每月进行血浆置换,4例观察到临床改善,通常病情加重次数减少。一名患者所有治疗均失败,病情持续严重加重。从这个简短的系列研究来看,血浆置换似乎对药物治疗无法完全控制的慢性白塞病有用。在这些病例中,应重复进行血浆置换。然而,需要更长时间的随访来证实这些结果。