大鼠大脑膜蛋白对腺苷酸环化酶的抑制作用。
Inhibition of adenylate cyclase by a membrane protein from rat cerebrum.
作者信息
Sano M, Kitajima S, Mizutani A
出版信息
Brain Res. 1983 Mar 28;264(1):157-9. doi: 10.1016/0006-8993(83)91135-6.
PMID:6682691
Abstract
The inhibitor protein of adenylate cyclase was partially purified from detergent-extract of rat brain. The inhibition occurred without lag phase. Calmodulin, GTP, guanyl 5'-yl imidodiphosphate (Gpp (NH) p) and forskolin did not change the inhibition, but activities stimulated by NaF or Mn2+ were more resistant for the inhibition. The inhibitor might include an essential sulfhydryl group.
摘要
腺苷酸环化酶抑制蛋白是从大鼠脑的去污剂提取物中部分纯化得到的。这种抑制作用没有延迟期。钙调蛋白、鸟苷三磷酸（GTP）、5'-鸟苷酰亚胺二磷酸（Gpp(NH)p）和福斯高林不会改变这种抑制作用，但氟化钠（NaF）或锰离子（Mn2+）刺激的活性对这种抑制作用更具抗性。该抑制剂可能含有一个必需的巯基。
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