Propranolol in schizophrenia.

1. 15 schizophrenic patients diagnosed according to criteria of I.C.D.-9 were treated with d1-propranolol in a 4 week open study. 2. A fixed dose schedule was followed and a maximum dose of 1920 mg/day was reached by day 17. 3. Results revealed a significant reduction in core schizophrenic symptoms of CPRS & BPRS starting between 1st and second weeks of therapy. Higher doses were well tolerated and serious bradycardia occurred only in 3 patients. 4. The implications of these results are discussed.