顺二氯二氨合铂治疗播散性恶性黑色素瘤
Cis-diamminedichloroplatinum in the treatment of disseminated malignant melanoma.
作者信息
Mechl Z, Krejcí P
出版信息
Neoplasma. 1983;30(3):371-7.
The efficacy of cis-platinum in the treatment of recurrent advanced malignant melanoma is discussed and also the so far unpublished clinical data have been summed up. On account of the considerable differences among these data the clinical study of Stage II had been started which should contribute to the elucidation of efficacy of cis-platinum in malignant melanoma treatment. Here the first part of the trial is presented in which cis-platinum was administered to 21 patients, and the effects were studied in 17 of them. In 5 patients a partial remission was observed. These results are considered to be satisfactory enough to offer further time on the study of effects of cis-platinum.
讨论了顺铂治疗复发性晚期恶性黑色素瘤的疗效，并总结了迄今未发表的临床数据。鉴于这些数据存在相当大的差异，已启动了II期临床研究，该研究应有助于阐明顺铂在恶性黑色素瘤治疗中的疗效。本文展示了该试验的第一部分，其中对21例患者给予顺铂，并对其中17例患者的效果进行了研究。5例患者出现部分缓解。这些结果被认为足够令人满意，足以进一步研究顺铂的效果。
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