Lindemann B A, Evans T L, McCall J W
Am J Vet Res. 1983 Nov;44(11):2170-2.
Six male and 6 female Beagles, 6 to 7 months old, were allotted to 2 groups: group I--inoculated subcutaneously with 30 Dipetalonema reconditum infective larvae/dog, and group II--noninoculated controls. Group comparisons were made in regard to hematologic values, Knott test results, body weights, blood urea nitrogen, total serum protein, serum albumin and alanine aminotransferase and creatine kinase activities. Routine urinalysis data were compared at 1 week before and at 28 weeks after the inoculations. Mean total leukocyte counts were significantly (P less than 0.05) greater in group I dogs than in group II dogs at postinoculation weeks (PIW) 4, 5, and 7 to 12, and mean eosinophil counts were significantly greater in group I dogs at PIW 3 to 11, 13 to 15, 20, and 23 to 24. Microfilariae were detected as early as the 10th week and sporadically thereafter. Only 1 D reconditum adult worm was recovered from all of the inoculated dogs. Five other dogs (group III) with chronic, patient experimentally induced dipetalonemiasis, were evaluated with the same tests at PIW 70 to 89. Eosinophilia (greater than 750 cells/microliter) was present in 4 of 5 dogs; lymphocytosis (greater than 4,800 cells/microliter) was evident in 1 dog. Proteinuria (greater than or equal to 30 mg/dl) was detected in 3 of 4 dogs with chronic dipetalonemiasis.
6只6至7月龄的雄性比格犬和6只同龄雌性比格犬被分为2组：第一组——每只犬皮下接种30条隐匿棘唇线虫感染性幼虫；第二组——未接种的对照组。对两组在血液学值、诺特氏试验结果、体重、血尿素氮、总血清蛋白、血清白蛋白以及丙氨酸转氨酶和肌酸激酶活性方面进行比较。在接种前1周和接种后28周比较常规尿液分析数据。接种后第4、5、7至12周，第一组犬的平均白细胞总数显著高于第二组犬（P<0.05），接种后第3至11、13至15、20以及23至24周，第一组犬的平均嗜酸性粒细胞计数显著更高。早在第10周就检测到微丝蚴，此后呈散在性出现。在所有接种犬中仅回收了1条隐匿棘唇线虫成虫。另外5只患有慢性实验性诱导棘唇线虫病的犬（第三组）在接种后第70至89周接受了相同检测。5只犬中有4只出现嗜酸性粒细胞增多（>750个细胞/微升）；1只犬出现淋巴细胞增多（>4800个细胞/微升）。4只患有慢性棘唇线虫病的犬中有3只检测到蛋白尿（≥30mg/dl）。
