编码人二氢叶酸还原酶的cDNA的核苷酸序列。
The nucleotide sequence of the cDNA coding for the human dihydrofolic acid reductase.
作者信息
Masters J N, Attardi G
出版信息
Gene. 1983 Jan-Feb;21(1-2):59-63. doi: 10.1016/0378-1119(83)90147-6.
The nucleotide sequence of the human dihydrofolic acid reductase (DHFR) reading frame has been derived from the analysis of human DHFR cDNA. This sequence and the corresponding amino acid sequence have been compared with those available for the enzyme and its coding segment from other organisms. There is an 89% nucleotide sequence homology between the human DHFR reading frame and the mouse coding sequence. Furthermore, amino acid-sequence homologies of 74%, 81% and 89% has been found between human DHFR and chicken, bovine and mouse DHFR, respectively.
人类二氢叶酸还原酶（DHFR）阅读框的核苷酸序列是通过对人类DHFR cDNA的分析得出的。该序列以及相应的氨基酸序列已与其他生物体中该酶及其编码片段的序列进行了比较。人类DHFR阅读框与小鼠编码序列之间存在89%的核苷酸序列同源性。此外，分别发现人类DHFR与鸡、牛和小鼠DHFR的氨基酸序列同源性为74%、81%和89%。
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