Zeng Y L, Akkermans A A, Breimer D D
Arzneimittelforschung. 1983;33(5):757-60.
During the development of a new computer program for the Loo-Riegelman method for the estimation of the rate drug absorption, it was found that many factors can affect the accuracy of the estimated absorption rate constant (ka). In this paper a survey of the factors affecting the errors in the estimation of ka by the Loo-Riegelman method is made. By simulating data and computer techniques, the effects of factors related to each step in the calculation procedure as well as the influence of certain pharmacokinetic parameters were studied in detail. If these factors are not well controlled, the estimated error in ka will become very large, in some cases even surpassing 30%. In addition, it was derived that careful attention has to be paid to both sampling time and the number of plasma samples. A "trial and error" method for obtaining an optimal sampling schedule that minimizes the error of ka is presented.
在开发一种用于鲁-里格尔曼法估算药物吸收速率的新计算机程序时,发现许多因素会影响估算的吸收速率常数(ka)的准确性。本文对鲁-里格尔曼法估算ka时影响误差的因素进行了综述。通过模拟数据和计算机技术,详细研究了计算过程中每个步骤相关因素的影响以及某些药代动力学参数的影响。如果这些因素控制不当,ka的估算误差会变得非常大,在某些情况下甚至超过30%。此外,还得出必须仔细关注采样时间和血浆样本数量的结论。提出了一种“试错”方法,用于获得使ka误差最小化的最佳采样方案。