Rubenson D, Griffin J C, Ford A, Claude J, Reitz B, Knutti J, Billingham M, Harrison D C
Am Heart J. 1984 Jan;107(1):90-6. doi: 10.1016/0002-8703(84)90139-x.
The necessity for conscious animal models in the study of cardiac physiology has been established for hemodynamics. The characterization of the electrophysiologic properties of the heart has not been performed in a serial fashion in a conscious animal model. Implanted telemetry sensing devices for recording atrial, ventricular, and His electrograms and stimulation systems for both atrium and ventricle allowed serial evaluation of eight dogs for up to 4 months. There were significant fluctuations in some electrophysiologic variables with time, particularly heart rate, sinus node recovery time, and pacing rate for induction of Wenckebach block. This variability did not appear to deviate with time after implantation, and no significant differences in the basal electrophysiologic state were found between the period early after surgery (0 to 2 1/2 weeks) and later (3 to 8 weeks).
在心脏生理学研究中，清醒动物模型对于血流动力学研究的必要性已得到确立。然而，尚未在清醒动物模型中对心脏电生理特性进行连续的表征。植入式遥测传感装置用于记录心房、心室和希氏束电图，以及心房和心室的刺激系统，可对8只犬进行长达4个月的连续评估。一些电生理变量随时间有显著波动，特别是心率、窦房结恢复时间以及诱发文氏阻滞的起搏频率。这种变异性在植入后似乎并未随时间而偏离，并且在术后早期（0至2.5周）和后期（3至8周）之间，基础电生理状态未发现显著差异。
