Fink R S, Mann M S, Hopewell J P, Ginsburg J
Postgrad Med J. 1984 Jan;60(699):66-9. doi: 10.1136/pgmj.60.699.66.
A 21-year-old man presented with a 16-year history of recurrent pyrexial episodes and a 5-year history of gynaecomastia. Blood and urinary oestrogen levels were elevated and a mass was found in the upper pole of a retractile right testis. After orchidectomy, oestrogen levels fell, gynaecomastia regressed and the pyrexial episodes ceased. Histological examination of the right testis showed a benign Leydig cell tumour in the upper pole and a germinal cell carcinoma in situ in the remaining part of the testis. Thus a potentially lethal condition was detected at an early pre-malignant phase by virtue of a benign, endocrinologically active tumour. This would seem to be the first report of the co-existence of a Leydig cell tumour and germ cell carcinoma in the same testis.
一名21岁男性，有16年反复发热病史及5年男性乳房发育史。血液和尿液中的雌激素水平升高，在回缩性右侧睾丸的上极发现一个肿块。睾丸切除术后，雌激素水平下降，男性乳房发育消退，发热发作停止。右侧睾丸组织学检查显示上极有一个良性间质细胞瘤，睾丸其余部分有原位生殖细胞癌。因此，借助一个良性的、具有内分泌活性的肿瘤，在恶性前期的早期阶段就检测出了一种潜在致命疾病。这似乎是同一睾丸中同时存在间质细胞瘤和生殖细胞癌的首例报告。
