土壤中的二噁英：大鼠和豚鼠摄入后的生物利用度。

Dioxin in soil: bioavailability after ingestion by rats and guinea pigs.

作者信息

McConnell E E, Lucier G W, Rumbaugh R C, Albro P W, Harvan D J, Hass J R, Harris M W

出版信息

Science. 1984 Mar 9;223(4640):1077-9. doi: 10.1126/science.6695194.

Abstract

Soil environmentally contaminated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) was given by gavage to guinea pigs and rats. The development of a characteristic clinicopathologic syndrome in guinea pigs, the induction of aryl hydrocarbon hydroxylase in rats, and the presence of TCDD in the livers of both species show that TCDD in soil exhibits high biological availability after ingestion.

摘要

用经口灌胃法将受2,3,7,8-四氯二苯并对二噁英（TCDD）污染的土壤给予豚鼠和大鼠。豚鼠出现特征性临床病理综合征、大鼠体内芳烃羟化酶的诱导以及两种动物肝脏中TCDD的存在表明，土壤中的TCDD在摄入后具有很高的生物利用度。