Nathanson M H, McLaren G D, Saidel G M
Comput Biomed Res. 1984 Feb;17(1):55-70. doi: 10.1016/0010-4809(84)90006-5.
A multicompartment model describing the physiological processes of intestinal iron absorption has been developed. The model accounts for uptake by the intestinal mucosa of iron in the lumen, followed by either iron incorporation into a mucosal storage pool (presumably ferritin) or direct iron transfer to the plasma. To enable analysis of iron absorption from noninvasive measurements, plasma iron kinetics were also analyzed. The model was validated in studies of three beagle dogs given oral 59Fe-citrate and intravenous 55Fe-transferrin simultaneously. Model parameters were estimated from the best (least-squares) fit of the model outputs to the tracer iron activity in venous blood samples and in the whole body. The parameter values show that both incorporation of iron into the mucosal storage pool and transfer of iron from the mucosa to the plasma occur at rates approximately 100 times greater than mucosal uptake of iron from the gut lumen. Further, release of iron from mucosal storage, while measurable, occurs at a slow rate. The study demonstrates the practicality of this noninvasive approach for the simultaneous study of iron absorption and plasma iron kinetics.
已建立了一个描述肠道铁吸收生理过程的多室模型。该模型考虑了肠腔内铁被肠黏膜摄取的情况，随后铁要么整合到黏膜储存池（推测为铁蛋白）中，要么直接转移到血浆中。为了能够从无创测量中分析铁吸收情况，还对血浆铁动力学进行了分析。该模型在同时给予3只比格犬口服59Fe - 柠檬酸盐和静脉注射55Fe - 转铁蛋白的研究中得到了验证。模型参数是通过将模型输出与静脉血样本和全身示踪铁活性进行最佳（最小二乘法）拟合来估计的。参数值表明，铁整合到黏膜储存池以及从黏膜转移到血浆的速率大约比肠黏膜从肠腔摄取铁的速率大100倍。此外，虽然可测量，但铁从黏膜储存中释放的速率很慢。该研究证明了这种无创方法用于同时研究铁吸收和血浆铁动力学的实用性。
