接种维斯纳病毒的小鼠的免疫反应性。
Immune reactivity of Visna virus-inoculated mice.
作者信息
Svennerholm B, Strannegård O, Lycke E
出版信息
Infect Immun. 1978 May;20(2):412-7. doi: 10.1128/iai.20.2.412-417.1978.
Visna virus inoculation of mice before immunization with unrelated antigens caused suppression of humoral and cell-mediated immune responses. The immunosuppressive effect was dependent on the virus dose and time of administration. The number of "background" antibody-producing spleen cells increased slightly after inoculation of Visna virus. Heat treatment of Visna virus abolished its immunosuppressive effect. Replication of Visna virus in mice seemed to be a prerequisite for its immunomodulating effect.
在用无关抗原免疫小鼠之前接种维斯纳病毒会导致体液免疫和细胞介导免疫反应受到抑制。免疫抑制作用取决于病毒剂量和给药时间。接种维斯纳病毒后，“背景”抗体产生脾细胞的数量略有增加。对维斯纳病毒进行热处理可消除其免疫抑制作用。维斯纳病毒在小鼠体内的复制似乎是其免疫调节作用的一个先决条件。
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