Racle J P, Maman G, Beligon C, Curabet D
Ann Fr Anesth Reanim. 1984;3(1):52-3. doi: 10.1016/s0750-7658(84)80100-8.
A case of carpipramine overdose is reported. The patient was admitted with ventricular tachycardia 4 h after taking 2.40 g of the drug. This disappeared at the sixth hour. In overdoses with other tricyclics, ventricular tachycardia was successfully treated within 30 min of starting a sodium lactate perfusion. In the case presented, reversal of the ventricular tachycardia coincided with the half-life of the drug; the effects of perfusing 1000 ml sodium lactate over 2 h seemed doubtful. This sodium resistance may be related to a relative hypokalemia (3.4 mmol X 1(-1) ). The use of sodium lactate for the treatment of overdoses with drugs with short-half lives appeared questionable.
报告了一例卡比咪嗪过量病例。患者在服用2.40克该药物4小时后因室性心动过速入院。这种情况在第六小时消失。在其他三环类药物过量时,在开始乳酸钠灌注30分钟内室性心动过速得到成功治疗。在本病例中,室性心动过速的逆转与药物的半衰期一致;在2小时内灌注1000毫升乳酸钠的效果似乎存疑。这种对钠的抵抗可能与相对低钾血症(3.4毫摩尔×1(-1))有关。使用乳酸钠治疗半衰期短的药物过量情况似乎存在问题。