Feinberg M, Carroll B J
Biol Psychiatry. 1984 Jan;19(1):3-11.
Several authors have shown that endogenous depressed patients have biological abnormalities which exist to a lesser extent in nonendogenous depressives and in normals, and have suggested that these biological abnormalities may be used as markers to classify depressed patients as endogenous or nonendogenous. We have investigated several of these biological abnormalities, and have explored the diagnostic classifications based on individual markers and on two or more markers in combination. The evaluation of combinations of diagnostic tests requires different statistical techniques than does the evaluation of single tests, and we discuss two such techniques: stepwise multiple regression and contingency table analysis. We report here our results with the dexamethasone suppression test (DST), EEG studies of sleep, and the amphetamine-stimulated release of growth hormone separately and in combination. The amphetamine-stimulated release of growth hormone was not diagnostically useful.
几位作者已经表明，内源性抑郁症患者存在生物学异常，这种异常在非内源性抑郁症患者和正常人中程度较轻，并提出这些生物学异常可作为将抑郁症患者分类为内源性或非内源性的标志物。我们研究了其中几种生物学异常，并探讨了基于单个标志物以及两个或多个标志物组合的诊断分类。诊断测试组合的评估需要与单个测试评估不同的统计技术，我们讨论了两种这样的技术：逐步多元回归和列联表分析。我们在此报告我们分别及联合进行地塞米松抑制试验（DST）、睡眠脑电图研究以及苯丙胺刺激的生长激素释放试验的结果。苯丙胺刺激的生长激素释放试验在诊断上并无用处。
