儿茶酚胺的性别差异与不对称性：与转向偏好的关系。

Sex differences and asymmetries of catecholamines: relation to turning preferences.

作者信息

Dark K A, Ellman G, Peeke H V, Galin D, Reus V I

出版信息

Pharmacol Biochem Behav. 1984 Mar;20(3):327-30. doi: 10.1016/0091-3057(84)90265-x.

Abstract

Male and female Sprague-Dawley rats were tested for turning preferences in a multiple alley maze. The left and right caudate-putamen were dissected and assayed for norepinephrine and dopamine. Dopamine was not found to be lateralized contralateral to turning preference for females as a group. However, dopamine was significantly lateralized contralateral to the females turning preference if a strong turning bias was present. No relationship between dopamine asymmetry and turning preference was evident for males. Females were found to have norepinephrine significantly lateralized to the left caudate-putamen; in males greater striatal norepinephrine levels were equally distributed between left and right sides. This sexual dimorphism in norepinephrine lateralization was not related to turning preference.

摘要

对雄性和雌性斯普拉格-道利大鼠在多通道迷宫中进行转向偏好测试。解剖左右尾状核-壳核并检测去甲肾上腺素和多巴胺。作为一个整体，未发现多巴胺在雌性转向偏好的对侧出现侧化。然而，如果存在强烈的转向偏好，多巴胺在雌性转向偏好的对侧会显著侧化。对于雄性，未发现多巴胺不对称与转向偏好之间存在明显关系。发现雌性的去甲肾上腺素显著侧化至左侧尾状核-壳核；而雄性纹状体中较高的去甲肾上腺素水平在左右两侧平均分布。去甲肾上腺素侧化的这种性别差异与转向偏好无关。