核苷酸生物合成的潜在抑制剂。2. 嘧啶核苷的卤代甲基酮衍生物。
Potential inhibitors of nucleotide biosynthesis. 2. Halomethyl ketone derivatives of pyrimidine nucleosides.
作者信息
Montgomery J A, Thomas H J, Brockman R W, Elliott R D
出版信息
J Med Chem. 1984 May;27(5):680-4. doi: 10.1021/jm00371a022.
PMID:6716405
Abstract
Several halomethyl ketone derivatives of pyrimidine nucleosides have been prepared for evaluation as cytotoxic agents. The first series are 1-(8-halo-2,5,6,8- tetradeoxy -beta-D-erythro-oct-7 - ulofuranosyl )thymines (7-9), whereas the second type are halo derivatives of acetophenone (12-14 and 16). These compounds are cytotoxic, and one (13) showed activity against the P388 leukemia in vivo.
摘要
已制备了几种嘧啶核苷的卤代甲基酮衍生物，以评估其作为细胞毒性剂的效果。第一类是1-(8-卤代-2,5,6,8-四脱氧-β-D-赤藓-辛-7-酮呋喃糖基)胸腺嘧啶(7-9)，而第二类是苯乙酮的卤代衍生物(12-14和16)。这些化合物具有细胞毒性，其中一种(13)在体内对P388白血病显示出活性。
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