Semenzato G, Agostini C, Pezzutto A, Gasparotto G, Cipriani A, Chilosi M, Pizzolo G
J Clin Lab Immunol. 1984 Jan;13(1):25-8.
A number of immunological abnormalities have been reported in sarcoidosis. In this paper an excess of Natural killer (NK) cells, as defined by the reactivity with HNK-1 monoclonal antibody, is demonstrated in peripheral blood of these patients. On the contrary, only a few HNK-1+ cells have been found among mononuclear cells infiltrating and/or surrounding sarcoid granulomas in the lungs, lymph nodes and skin. While NK cell activity may represent one of the first lines of natural resistance against foreign antigens, the lack of killing in involved tissue gives no support for control of sarcoidosis by NK cells at sites of disease activity. Possible interpretations of these findings are discussed.
结节病患者已报告有许多免疫异常情况。本文证实，这些患者外周血中存在过量的自然杀伤（NK）细胞，这是通过与HNK-1单克隆抗体的反应性来定义的。相反，在肺部、淋巴结和皮肤中浸润和/或包围结节病肉芽肿的单核细胞中，仅发现少数HNK-1+细胞。虽然NK细胞活性可能代表对外来抗原的第一道天然防线，但在受累组织中缺乏杀伤作用，这无法支持NK细胞在疾病活动部位对结节病进行控制。文中讨论了这些发现的可能解释。
