Conlogue G, Foreyt W J, Wescott R B
Am J Vet Res. 1984 May;45(5):863-6.
Twenty coccidia-free Holstein bull calves were allotted to groups to study effects of treatment with lasalocid and decoquinate on subsequent resistance to coccidiosis (Eimeria spp infections). Calves fed medicated rations of either drug at dosages of 50 mg/kg of feed (approx 1.2 mg/kg of body weight) had significantly fewer oocysts (P less than 0.01) than did nontreated controls regardless of other procedures used. Treated calves premunized with 2,000 oocysts/day for 5 days and later challenge inoculated with 200,000 oocysts did not develop diarrhea, unless the drugs were withdrawn from feed. Animals premunized (2,000 oocysts/day for 5 days) in absence of drug were no more resistant to the challenge inoculation than nonpremunized animals. These results indicated that lasalocid and decoquinate were efficacious coccidiostats and protected calves as long as they were administered. Cessation of drug treatment usually resulted in appearance of oocysts in feces and diarrhea. Premunization alone cannot be expected to prevent coccidiosis when animals are exposed to large numbers of oocysts.
将20头无球虫的荷斯坦公牛犊分组，以研究用拉沙洛西和地克珠利治疗对随后抗球虫病（艾美耳属感染）能力的影响。无论采用其他何种程序，以50毫克/千克饲料（约1.2毫克/千克体重）的剂量饲喂任何一种药物的药饵的犊牛，其卵囊数量均显著少于未治疗的对照组（P小于0.01）。用2000个卵囊/天连续处理5天进行预免疫，随后接种200,000个卵囊进行攻毒的犊牛，除非停止在饲料中添加药物，否则不会出现腹泻。在无药物的情况下用2000个卵囊/天连续处理5天进行预免疫的动物，对攻毒接种的抵抗力并不比未预免疫的动物更强。这些结果表明，拉沙洛西和地克珠利是有效的抗球虫药，只要给药就能保护犊牛。停止药物治疗通常会导致粪便中出现卵囊和腹泻。当动物接触大量卵囊时，仅靠预免疫不能预防球虫病。
