苯巴比妥对酶的诱导作用及人体中维生素K1的代谢处置
Enzyme induction by phenobarbitone and vitamin K1 disposition in man.
作者信息
Park B K, Wilson A C, Kaatz G, Ohnhaus E E
出版信息
Br J Clin Pharmacol. 1984 Jul;18(1):94-7. doi: 10.1111/j.1365-2125.1984.tb05028.x.
Abstract
The plasma disposition of an intravenous pharmacological dose of vitamin K1 was determined in seven healthy volunteers before and after chronic administration of phenobarbitone (100 mg nocte). Phenobarbitone produced a significant increase in antipyrine clearance and 6 beta-hydroxycortisol excretion in all volunteers, indicating induction of hepatic microsomal mixed-function oxidase enzymes. However, phenobarbitone administration had no effect on the plasma disposition of vitamin K1. We conclude therefore, that vitamin K1 is not metabolized to any significant extent, by phenobarbitone-inducible mixed-function oxidase enzymes.
摘要
在七名健康志愿者中，测定了长期服用苯巴比妥（每晚100毫克）前后静脉注射药理剂量维生素K1后的血浆处置情况。苯巴比妥使所有志愿者的安替比林清除率和6β-羟基皮质醇排泄量显著增加，表明肝微粒体混合功能氧化酶被诱导。然而，服用苯巴比妥对维生素K1的血浆处置没有影响。因此，我们得出结论，维生素K1在很大程度上不会被苯巴比妥诱导的混合功能氧化酶代谢。
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