人类大肠肿瘤中的染色体。对1号染色体的研究。

Chromosomes in human large bowel tumors. A study of chromosome #1.

作者信息

Reichmann A, Martin P, Levin B

出版信息

Cancer Genet Cytogenet. 1984 Aug;12(4):295-301. doi: 10.1016/0165-4608(84)90062-1.

Abstract

Chromosome studies on 49 patients with large bowel adenocarcinomas showed abnormalities of chromosome #1 in 19 cases (39%). One had monosomy, 13 showed trisomy, and 5 cases had structural abnormalities. Eighteen patients had tumors on the right side of the colon; of these, only 3 had an abnormal #1 (17%); 16 of 28 tumors (57%) located on the left side had abnormalities of #1. The regions of consistent duplication of 1q were q24----q44? The presence or absence of changes of chromosome #1 may be useful as a prognostic indicator in large bowel cancer.

摘要

对49例大肠腺癌患者进行的染色体研究显示，19例（39%）存在1号染色体异常。1例为单体型，13例为三体型，5例存在结构异常。18例患者的肿瘤位于结肠右侧；其中只有3例1号染色体异常（17%）；28例位于左侧的肿瘤中有16例（57%）存在1号染色体异常。1q一致重复的区域为q24----q44？1号染色体变化的有无可能作为大肠癌的预后指标。