维洛沙嗪对癫痫患者血清卡马西平水平的影响。

Effect of viloxazine on serum carbamazepine levels in epileptic patients.

作者信息

Pisani F, Narbone M C, Fazio A, Crisafulli P, Primerano G, D'Agostino A A, Oteri G, Di Perri R

出版信息

Epilepsia. 1984 Aug;25(4):482-5. doi: 10.1111/j.1528-1157.1984.tb03447.x.

DOI:10.1111/j.1528-1157.1984.tb03447.x

Abstract

The present study describes the interaction between carbamazepine (CBZ) and viloxazine, a recently synthesized antidepressant agent. Seven epileptic patients on chronic anticonvulsant therapy showed a significant (p less than 0.005) increase in steady-state serum CBZ levels (from 8.1 +/- 2.5 SD to 12.1 +/- 2.5 SD micrograms/ml) when viloxazine (300 mg/day) was added to the therapy. The effect was associated with the appearance of mild CBZ intoxication. The symptoms of this intoxication (i.e., dizziness, ataxia, fatigue, drowsiness) disappeared rapidly, and serum CBZ levels decreased to the basal values, when viloxazine administration was stopped.

摘要

本研究描述了卡马西平（CBZ）与最近合成的抗抑郁药维洛沙嗪之间的相互作用。7名接受慢性抗惊厥治疗的癫痫患者在治疗中添加维洛沙嗪（300毫克/天）后，稳态血清CBZ水平显著升高（p小于0.005）（从8.1±2.5标准差微克/毫升升至12.1±2.5标准差微克/毫升）。该效应与轻度CBZ中毒的出现有关。停止服用维洛沙嗪后，这种中毒症状（即头晕、共济失调、疲劳、嗜睡）迅速消失，血清CBZ水平降至基础值。