与细胞基质相关的组装。
Assembly associated with the cytomatrix.
作者信息
Fulton A B
出版信息
J Cell Biol. 1984 Jul;99(1 Pt 2):209s-211s. doi: 10.1083/jcb.99.1.209s.
Abstract
Assembly in vivo has been studied both for endogenous cytoskeletal proteins and for several classes of viruses. Autoradiography of cytoskeletal proteins has shown that many associate with the cytoskeletal framework close to the time and place of synthesis. The cytoskeletal proteins rearrange after association with the cytoskeletal framework. Rearrangement in symmetrical giant cells occurs in a centrifugal and coherent pattern. Many of the cytoskeletal proteins associate cotranslationally, as shown by their puromycin resistance in a cell-free translation system. The assembly of several groups of viruses has been shown to be associated with various components of the cytoskeleton; whether such assembly is cotranslational has not yet been addressed directly.
摘要
体内组装已针对内源性细胞骨架蛋白和几类病毒进行了研究。细胞骨架蛋白的放射自显影显示，许多蛋白在合成的时间和地点附近与细胞骨架框架结合。细胞骨架蛋白与细胞骨架框架结合后会重新排列。对称巨细胞中的重新排列以离心和连贯的模式发生。许多细胞骨架蛋白在翻译过程中共同结合，这在无细胞翻译系统中通过它们对嘌呤霉素的抗性得到证明。几组病毒的组装已被证明与细胞骨架的各种成分有关；这种组装是否是共翻译的尚未直接解决。
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