Liszczak T M, Black P M, Tzouras A, Foley L, Zervas N T
J Neurosurg. 1984 Sep;61(3):486-93. doi: 10.3171/jns.1984.61.3.0486.
Experimental subarachnoid hemorrhage (SAH) was induced in adult rabbits by three repeated cisterna magna injections of autologous nonheparinized blood. One week after the last blood injection the animals were sacrificed and examined for morphological change. No vasculopathy was noted in the basilar arteries and no periarterial thrombus was seen around the majority of these arteries. Gross and microscopic changes were observed in both the ventricles and choroid plexus. Ventricular changes included dilation of the lateral ventricles, destruction of ciliated ependymal cells, and deposition of small amounts of blood throughout the ventricular system. These ventricular changes are similar to the pathological sequelae of SAH in patients. Choroid plexus changes included electron-dense cytoplasmic inclusions and dilation of the lateral and subcellular spaces. The ventricular surface and the choroid plexus are both affected by the intracisternal injection of blood. The hydrocephalus that follows SAH may be potentiated by ependymal disruption and loss of ciliated activity in the ventricles. Changes in choroid plexus function may also occur.
通过向成年兔的小脑延髓池重复三次注射自体非肝素化血液诱导实验性蛛网膜下腔出血（SAH）。在最后一次注射血液一周后，处死动物并检查形态学变化。在基底动脉中未发现血管病变，并且在大多数这些动脉周围未观察到动脉周围血栓形成。在脑室和脉络丛中均观察到大体和微观变化。脑室变化包括侧脑室扩张、纤毛室管膜细胞破坏以及在整个脑室系统中少量血液沉积。这些脑室变化类似于SAH患者的病理后遗症。脉络丛变化包括电子致密的细胞质内含物以及侧间隙和亚细胞间隙扩张。脑室表面和脉络丛均受到脑池内注射血液的影响。SAH后发生的脑积水可能因脑室室管膜破坏和纤毛活动丧失而加重。脉络丛功能也可能发生变化。
