Das U N
Int J Tissue React. 1982;4(2):127-32.
Atherosclerosis is a curious process of the intima of the vessel walls characterized by platelet aggregation, deposition of thrombotic material, lipid and fibrin which finally culminates in the intimal thickening, vascularization, and haemorrhage from the new vessels. The lipids demonstrated in the atherosclerotic plaque are mainly cholesterol, triglycerides, and phospholipids. Hyperlipidaemia initiates and maintains the atherosclerotic process and a diet rich in unsaturated essential fatty acids is known to be of benefit in arresting the process. Prostaglandins are formed from unsaturated essential fatty acids and are known to regulate platelet aggregation and thrombus formation. Thus atherosclerosis may be a disease of altered PG system and if so this would pave the way for new therapeutic strategies.
动脉粥样硬化是血管壁内膜的一种奇特病变过程，其特征为血小板聚集、血栓物质沉积、脂质和纤维蛋白沉积，最终导致内膜增厚、血管形成以及新生血管出血。动脉粥样硬化斑块中显示的脂质主要是胆固醇、甘油三酯和磷脂。高脂血症启动并维持动脉粥样硬化过程，已知富含不饱和必需脂肪酸的饮食有助于阻止该过程。前列腺素由不饱和必需脂肪酸形成，已知可调节血小板聚集和血栓形成。因此，动脉粥样硬化可能是一种前列腺素系统改变的疾病，如果是这样，这将为新的治疗策略铺平道路。
