Job C K, Kirchheimer W F, Sanchez R M
Int J Lepr Other Mycobact Dis. 1982 Jun;50(2):177-82.
In this preliminary report the histopathological appearance of the lepromin reaction in armadillos was correlated with their response to infection with M. leprae. Three different types of lepromin response were described, namely the lepromatous, the borderline, and the tuberculoid lepromin reactions. It was found that 10 out of the 11 animals with a lepromatous lepromin reaction and the one animal with a borderline lepromin reaction developed disseminated disease. The two with a tuberculoid lepromin reaction and one of the 11 with a lepromatous lepromin reaction failed to develop leprosy. It is suggested that by using the lepromin response it is possible to assess, to a great extent, the susceptibility of armadillos to infection by M. laprae. The pros and cons of using the armadillo as an animal model for a vaccine trial are briefly discussed.
在本初步报告中，犰狳麻风菌素反应的组织病理学表现与其对麻风分枝杆菌感染的反应相关。描述了三种不同类型的麻风菌素反应，即瘤型、界线类和结核样型麻风菌素反应。发现11只出现瘤型麻风菌素反应的动物中有10只以及1只出现界线类麻风菌素反应的动物发生了播散性疾病。2只出现结核样型麻风菌素反应的动物以及11只出现瘤型麻风菌素反应的动物中的1只未患麻风病。建议通过使用麻风菌素反应，在很大程度上可以评估犰狳对麻风分枝杆菌感染的易感性。简要讨论了将犰狳用作疫苗试验动物模型的利弊。
