Yamagata S, Carter L P, Erspamer R
Stroke. 1982 Sep-Oct;13(5):680-6. doi: 10.1161/01.str.13.5.680.
Correlation of cortical blood flow as measured by a thermal diffusion flow probe (CBFp) with the direct cortical response (DCR) was studied in 48 lightly anesthetized cats with global ischemia. Thresholds for attenuation and loss of DCR were 21.3 +/- 4.7 and 8.7 and 3.4 ml/100 g/min respectively. In abrupt ischemia, CBFp of 0-3 ml/100 g/min produced absence of DCR in 6 min or less; however, at CBFp of 5-10 ml/100 g/min, the time to obliteration of DCR varied from 5 to 180 min. DCR was unlikely to recover after 13 min of 0-2 ml/100 g/min and after 35 min of 4-5 ml/100 g/min. At higher flows, DCR could recover over 60 min or more of ischemia. With gradual production of ischemia, flows less than 20 ml/100 g/min for over 60 min had a detrimental effect upon recovery of DCR if DCR was lost for 7.5 min or more. Some evidence that implied adaptability of the cortex to ischemia was found.
在48只轻度麻醉的存在全脑缺血的猫中，研究了用热扩散血流探头测量的皮质血流（CBFp）与直接皮质反应（DCR）之间的相关性。DCR衰减和消失的阈值分别为21.3±4.7以及8.7和3.4毫升/100克/分钟。在急性缺血中，CBFp为0 - 3毫升/100克/分钟时，6分钟或更短时间内DCR消失；然而，当CBFp为5 - 10毫升/100克/分钟时，DCR消失的时间从5分钟到180分钟不等。在CBFp为0 - 2毫升/100克/分钟持续13分钟以及4 - 5毫升/100克/分钟持续35分钟后，DCR不太可能恢复。在更高的血流情况下，DCR在缺血60分钟或更长时间后可能恢复。在逐渐产生缺血的情况下，如果DCR消失7.5分钟或更长时间，超过60分钟血流低于20毫升/100克/分钟会对DCR的恢复产生不利影响。发现了一些表明皮质对缺血具有适应性的证据。
