Gasic S
Cardiology. 1982;69 Suppl:209-24. doi: 10.1159/000173557.
In open and double-blind trials, tiapamil was given intravenously and/or orally to 22 patients with coronary heart disease and exertional angina. Multistage bicycle exercise tests were performed before and after drug treatment and patients acted as their own controls. Thallium-201 exercise myocardial imaging was also performed. Exercise tolerance increased and angina was improved under tiapamil treatment. Heart rate and blood pressure decreased slightly, consistent with reduced myocardial oxygen demand. Myocardial oxygen consumption, as indicated by the pressure-rate product, varied little, but exercise myocardial imaging indicated an increase in regional perfusion. The findings suggest that tiapamil is an effective antianginal agent.
在开放和双盲试验中，对22例冠心病和劳力性心绞痛患者静脉内和/或口服给予硫氮䓬酮。在药物治疗前后进行多级自行车运动试验，患者自身作为对照。还进行了铊-201运动心肌显像。在硫氮䓬酮治疗下运动耐量增加，心绞痛得到改善。心率和血压略有下降，这与心肌需氧量降低一致。压力-心率乘积所显示的心肌耗氧量变化不大，但运动心肌显像显示局部灌注增加。这些发现提示硫氮䓬酮是一种有效的抗心绞痛药物。
