Friedlaender G E, Mankin H J
Instr Course Lect. 1981;30:36-55.
There is considerable evidence to support the clinical usefulness of preserved osteochondral allografts in reconstructive orthopaedic surgery. Responsible methods for banking these tissues are required to provide biologically useful and predictable grafts that are free of potentially significant pathogenic agents or transmissible disease. Although much remains unknown concerning the biology, immunology, and biomechanics of fresh and preserved osteochondral allografts and undoubtedly the best method or methods for banking these tissues have not been identified, the approach outlined here (and in the AATB Guidelines) reflects our interpretation of the present state of the art. We fully recognize the possibility that alternative approaches may meet special needs of other investigators and, in fact, expect our approach to change as additional knowledge becomes available and as clinical applications expand.
有大量证据支持保存的骨软骨异体移植在重建整形外科手术中的临床实用性。需要有负责的方法来储存这些组织，以提供生物学上有用且可预测的移植物，这些移植物应不含潜在的重要病原体或传染病。尽管关于新鲜和保存的骨软骨异体移植的生物学、免疫学和生物力学仍有许多未知之处，而且毫无疑问尚未确定储存这些组织的最佳方法，但此处概述的方法（以及AATB指南中的方法）反映了我们对当前技术水平的理解。我们充分认识到替代方法可能满足其他研究者特殊需求的可能性，事实上，随着更多知识的获得以及临床应用的扩展，我们预计我们的方法将会改变。
