人单核细胞的抗体依赖性细胞介导的抗菌活性。II. 抗脑膜炎球菌活性的免疫特异性。

Antibody-dependent cell-mediated antibacterial activity of human mononuclear cells. II. Immune specificity of antimeningococcal activity.

作者信息

Smith L F, Lowell G H

出版信息

J Infect Dis. 1980 Jun;141(6):748-51. doi: 10.1093/infdis/141.6.748.

DOI:10.1093/infdis/141.6.748

Abstract

Antibody-dependent activity against group C meningococci mediated by human mononuclear cells or purified lymphocytes was inhibited when sera from adults immunized with group C meningococcal polysaccharide were preincubated with that polysaccharide. Likewise, activity against group A meningococci induced by heat-inactivated sera from adults immunized with group A meningococcal polysaccharide was inhibited by preincubation with that polysaccharide. Neither heterologous polysaccharide nor homologous protein or lipopolysaccharide meningococcal antigens inhibited the activity of either of these sera. The data indicate that immune specificity in this cell-mediated antibacterial system is dependent upon antibodies to the specific polysaccharide antigen with which the serum donor had been immunized.

摘要

当用C群脑膜炎球菌多糖免疫的成人血清与该多糖预孵育时，人单核细胞或纯化淋巴细胞介导的针对C群脑膜炎球菌的抗体依赖性活性受到抑制。同样，用A群脑膜炎球菌多糖免疫的成人热灭活血清诱导的针对A群脑膜炎球菌的活性，在与该多糖预孵育后也受到抑制。异源多糖或同源蛋白质或脂多糖脑膜炎球菌抗原均未抑制这两种血清中的任何一种的活性。数据表明，在这种细胞介导的抗菌系统中，免疫特异性取决于血清供体所免疫的特定多糖抗原的抗体。