锂对大鼠条件性味觉厌恶的中枢和外周作用

Central and peripheral effects of lithium on conditioned taste aversions in rats.

作者信息

Smith D F

出版信息

Psychopharmacology (Berl). 1980;68(3):315-7. doi: 10.1007/BF00428123.

Abstract

Central and peripheral injections of LiCl were given to rats to see whether conditioned taste aversions are caused by central or peripheral effects of Li. Rats received an IP injection of either 150 mmol/l LiCl or 150 mmol/l NaCl and a bilateral intracerebroventricular (ICV) injection of either 150 mmol/l LiCl, 150 mmol/l NaCl, or artificial cerebrospinal fluid (CSF) after drinking saccharin solution. Subsequent saccharin intake decreased in rats which received the IP LiCl injection, but failed to depend on which ICV injection had been given. The concentration of Li in bain and CSF was higher 0.5, 1.5, and 4 h after the ICV LiCl injection than after the IP LiCl injection, while the reverse was true for the plasma Li level. It is concluded that conditioned taste aversions are mediated by peripheral effects of Li.

摘要

向大鼠进行中枢和外周注射氯化锂，以观察条件性味觉厌恶是由锂的中枢效应还是外周效应引起的。大鼠在饮用糖精溶液后，接受腹腔注射150 mmol/l氯化锂或150 mmol/l氯化钠，以及双侧脑室内（ICV）注射150 mmol/l氯化锂、150 mmol/l氯化钠或人工脑脊液（CSF）。接受腹腔注射氯化锂的大鼠随后的糖精摄入量减少，但这并不取决于所给予的脑室内注射。脑室内注射氯化锂后0.5、1.5和4小时，脑和脑脊液中的锂浓度高于腹腔注射氯化锂后，而血浆锂水平则相反。得出的结论是，条件性味觉厌恶是由锂的外周效应介导的。