雄激素对去势大鼠视前区多巴胺能神经元的抑制作用。

Inhibitory effects of androgens on preoptic area dopaminergic neurons in castrate rats.

作者信息

Simpkins J W, Kalra P S, Kalra S P

出版信息

Neuroendocrinology. 1980 Sep;31(3):177-81. doi: 10.1159/000123070.

Abstract

The present study was undertaken to determine the effects of androgen implants in the preoptic area-suprachiasmatic nucleus (POA-SCN) on catecholamine turnover in the POA-SCN and the medial basal hypothalamus (MBH) in orchidectomized rats. Bilateral implants of testosterone (T) or dihydrotestosterone (DHT) in the POA-SCN of orchidectomized rats did not affect serum concentrations of LH and FSH or the turnover of dopamine (DA) and norepinephrine (NE) in the MBH. In the area surrounding the implants in the POA-SCN, T and DHT decreased dopamine turnover by 67 and 37%, respectively, without influencing the POA-SCN norepinephrine turnover. These results indicate (i) that T implants in the POA-SCN selectively depress POA-SCN dopamine turnover, (ii) that this effect of T may occur following its conversion to DHT, and (iii) that these androgen effects probably do not mediate the negative feedback action of T on gonadotropin secretion.

摘要

本研究旨在确定在去势大鼠的视前区-视交叉上核（POA-SCN）植入雄激素对POA-SCN和内侧基底下丘脑（MBH）中儿茶酚胺代谢率的影响。在去势大鼠的POA-SCN中双侧植入睾酮（T）或双氢睾酮（DHT），并不影响血清促黄体生成素（LH）和促卵泡生成素（FSH）的浓度，也不影响MBH中多巴胺（DA）和去甲肾上腺素（NE）的代谢率。在POA-SCN植入物周围区域，T和DHT分别使多巴胺代谢率降低了67%和37%，而不影响POA-SCN中的去甲肾上腺素代谢率。这些结果表明：（i）在POA-SCN中植入T可选择性地抑制POA-SCN中的多巴胺代谢率；（ii）T的这种作用可能在其转化为DHT后发生；（iii）这些雄激素作用可能并不介导T对促性腺激素分泌的负反馈作用。