阿司匹林及其他环氧化酶抑制剂的潜在治疗应用。
Potential therapeutic applications of aspirin and other cyclo-oxygenase inhibitors.
作者信息
Farah A E, Rosenberg F
出版信息
Br J Clin Pharmacol. 1980 Oct;10 Suppl 2(Suppl 2):261S-278S. doi: 10.1111/j.1365-2125.1980.tb01809.x.
Abstract
1 The ubiquitous actions of the cyclo-oxygenase inhibitors are described. 2 These include the inhibitory effect on prostaglandin synthesis and the direct effect of aspirin on lymphocytes and their ability to produce lymphokines. 3 Aspirin reduces some types of platelet aggregation possibly involving inhibition of the precursors of thromboxane A2 and prostacyclin. 4 The therapeutic implications in relation to transient ischaemic attacks, coronary artery disease and reno-allograft rejection are discussed. 5 The beneficial and adverse effects on the gastro-intestinal tract are described. 6 The effects of aspirin-like drugs on the genito-urinary tract are described with particular reference to their adverse effects on labour and their therapeutic effect on dysmenorrhoea.
摘要
- 描述了环氧化酶抑制剂的广泛作用。2. 这些作用包括对前列腺素合成的抑制作用以及阿司匹林对淋巴细胞及其产生淋巴因子能力的直接作用。3. 阿司匹林可减少某些类型的血小板聚集，这可能涉及对血栓素A2和前列环素前体的抑制。4. 讨论了其在短暂性脑缺血发作、冠状动脉疾病和肾移植排斥反应方面的治疗意义。5. 描述了对胃肠道的有益和不良影响。6. 描述了阿司匹林样药物对泌尿生殖道的影响，特别提及它们对分娩的不良影响以及对痛经的治疗作用。
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