醋酸环丙孕酮对男性性犯罪者血清睾酮、促黄体生成素、促卵泡生成素和催乳素的影响。

The effect of cyproterone acetate on serum testosterone, LH, FSH, and prolactin in male sexual offenders.

作者信息

Jeffcoate W J, Matthews R W, Edwards C R, Field L H, Besser G M

出版信息

Clin Endocrinol (Oxf). 1980 Aug;13(2):189-95. doi: 10.1111/j.1365-2265.1980.tb01041.x.

DOI:10.1111/j.1365-2265.1980.tb01041.x

Abstract

The anti-androgen, cyproterone acetate, was administered in a dose of 100 mg/day to eight adult male sexual offenders for 21-31 days. Serum testosterone fell to subnormal levels within 7 days and remained low for 6-28 days after treatment was stopped. The fall in testosterone was accompanied by a fall in serum luteinizing hormone (LH) and follicle stimulating hormone (FSH), and a rise in serum prolactin. All subjects experienced a decrease in libido and in frequency of masturbation. The probable mechanisms of action of cyproterone acetate are discussed, as is its potential role in the management of sexual offenders. These studies suggest that measurement of serum testosterone could be used as an index of compliance in sexual offenders treated with cyproterone acetate who are released on parole.

摘要

给8名成年男性性犯罪者服用抗雄激素醋酸环丙孕酮，剂量为100毫克/天，持续21 - 31天。血清睾酮在7天内降至正常水平以下，并在停药后6 - 28天内维持在低水平。睾酮下降伴随着血清黄体生成素（LH）和卵泡刺激素（FSH）下降，以及血清催乳素升高。所有受试者的性欲和手淫频率均降低。文中讨论了醋酸环丙孕酮可能的作用机制及其在性犯罪者管理中的潜在作用。这些研究表明，血清睾酮的测定可作为接受醋酸环丙孕酮治疗后假释的性犯罪者依从性的指标。