血型基因的染色体定位。

Chromosomal mapping of the blood group genes.

作者信息

Tippett P

出版信息

Semin Hematol. 1981 Jan;18(1):4-12.

Abstract

The assignment of blood group loci proceeds more slowly than that of biochemical markers, since it depends largely on pedigree analysis and these studies take longer to achieve significance than some of the rapid modern methods. However, seven structural blood group loci ABO, MNSs, Rh, Fy, Sc, Xg, and Ch--Rg are confidently assigned, and four more provisionally or tentatively sited. Other loci are recognized as part of linkage groups that will help in the eventual assignment to their chromosomes. There is little linkage information, and no assignments, for other independent loci involved in the expression of the ABO, Pl, Rh, and Lu loci.

摘要

血型基因座的定位比生化标记的定位进展要慢，因为这在很大程度上依赖于系谱分析，而且这些研究要比一些快速的现代方法花费更长的时间才能取得显著成果。然而，七个结构血型基因座ABO、MNSs、Rh、Fy、Sc、Xg和Ch-Rg已被确定，另外四个已被临时或初步定位。其他基因座被认为是连锁群的一部分，这将有助于最终将它们定位到染色体上。对于ABO、Pl、Rh和Lu基因座表达所涉及的其他独立基因座，几乎没有连锁信息，也没有定位结果。