Ackermann R H
Infusionsther Klin Ernahr. 1981 Feb;8(1):9-15.
As previously observed after infusions of glycerol, fructose infusions with rates above the average maximal turnover capacity (3.5 g X kg-1 X h-1) result in damage of the kidneys as shown by a decrease of the total activity of glycerokinase and fructokinase and excretion of glycerokinase in the urine. Beginning alterations of the kidneys are dependent on time and dose become evident by a depletion of protein per gram fresh weight. In the beginning of the changes the total activity of enzymes in the kidneys remaining constant. Interrelations between the observed kidney alterations, turnover capacity, substrate concentrations in the blood, and the rate of renal excretion are discussed with regard to the results after infusions of glucose and mannitol. For infusion therapy it can be deduced, that dosage in borderline cases should be determined by the blood level of the substrate rather than by body weight, if undesirable effects are to be avoided.
正如先前在输注甘油后所观察到的那样，果糖输注速率高于平均最大周转率（3.5 g·kg⁻¹·h⁻¹）时，会导致肾脏损伤，表现为甘油激酶和果糖激酶的总活性降低以及尿中甘油激酶的排泄。肾脏的早期改变取决于时间和剂量，每克鲜重蛋白质的消耗可明显显示出这种改变。在变化初期，肾脏中酶的总活性保持不变。根据葡萄糖和甘露醇输注后的结果，讨论了所观察到的肾脏改变、周转率、血液中底物浓度以及肾脏排泄速率之间的相互关系。对于输液治疗，可以推断出，如果要避免不良影响，在临界情况下，剂量应由底物的血药浓度而非体重来确定。
