Annunziata P, Federico A
J Neurol Sci. 1981 Feb;49(2):325-8. doi: 10.1016/0022-510x(81)90088-5.
Several glycosidase activities were measured in frontal gray matter of 4 brains from subjects affected by Creutzfeldt-Jakob disease. The changes of N-acetyl-beta-glucosaminidase, N-acetyl-beta-galactosaminidase, beta-glucosidase, alpha-fucosidase and alpha-mannosidase were not statistically significant but significant increases of beta-glucuronidase and beta-galactosidase activities were found. These results are in accordance with several reports on brain glycosidases in scrapie and Semliki Forest virus-infected brain and could explain some changes in brain glycoconjugate content previously observed in human and experimental Creutzfeldt-Jakob disease.
对4例克雅氏病患者大脑额叶灰质中的几种糖苷酶活性进行了测定。N-乙酰-β-氨基葡萄糖苷酶、N-乙酰-β-半乳糖苷酶、β-葡萄糖苷酶、α-岩藻糖苷酶和α-甘露糖苷酶的变化无统计学意义,但发现β-葡萄糖醛酸酶和β-半乳糖苷酶活性显著增加。这些结果与关于羊瘙痒病和Semliki森林病毒感染大脑中脑糖苷酶的几份报告一致,并且可以解释先前在人类和实验性克雅氏病中观察到的脑糖缀合物含量的一些变化。