血小板与凝血蛋白。

Platelets and coagulation proteins.

作者信息

Walsh P N

出版信息

Fed Proc. 1981 May 15;40(7):2086-91.

Abstract

Platelets participate in hemostasis in part by their complex interrelationships with coagulation proteins. Several intrinsic platelet proteins are present in alpha-granules (fibrinogen, factor V, factor VIII antigen, platelet factor 4), in the cytosol (factor XIII), or in the membrane fraction (factor XI). Platelets also contribute to surface-mediated zymogen activations of plasma factors XII, XI, X, and prothrombin and bind several coagulation proteins including factor Xa, thrombin, and fibrinogen. Finally, platelets can protect coagulation enzymes (factors XIa and Xa) from inactivation by plasma proteinase inhibitors. Thereby intrinsic coagulation reactions occur preferentially on the platelet surface leading to fibrin formation within and around platelet plugs.

摘要

血小板部分通过与凝血蛋白的复杂相互关系参与止血过程。几种内在血小板蛋白存在于α颗粒（纤维蛋白原、因子V、因子VIII抗原、血小板因子4）、胞质溶胶（因子XIII）或膜部分（因子XI）中。血小板还参与血浆因子XII、XI、X和凝血酶原的表面介导酶原激活，并结合几种凝血蛋白，包括因子Xa、凝血酶和纤维蛋白原。最后，血小板可以保护凝血酶（因子XIa和Xa）不被血浆蛋白酶抑制剂灭活。因此，内源性凝血反应优先在血小板表面发生，导致在血小板凝块内部和周围形成纤维蛋白。