Davoine G A, Jung A, Courvoisier B
Schweiz Med Wochenschr. 1981 Apr 11;111(15):518-24.
During the past 6 years 16 patients suffering from Paget's disease of bone have been treated and regularly followed up in our department. 10 of these patients have received etidronate (ethane-hydroxy-diphosphonate), 4 others have received synthetic human calcitonin and the last 2 have received both treatments, first successively then simultaneously. Under either therapy satisfactory clinical and biological results have been observed (diminution of pain and decreased levels of serum alkaline phosphatase and hydroxyprolinuria). Etidronate has been more efficient in reducing biological parameters, whereas calcitonin has produced a faster symptomatic response. On the basis of these observations the present principles for treatment of Paget's disease are discussed.
在过去6年中，我们科室共治疗了16例骨佩吉特病患者，并对其进行了定期随访。其中10例患者接受了依替膦酸（乙烷-羟基-二膦酸）治疗，另外4例接受了合成人降钙素治疗，最后2例患者先先后接受了这两种治疗，然后同时接受了这两种治疗。在任何一种治疗方法下，都观察到了令人满意的临床和生物学结果（疼痛减轻以及血清碱性磷酸酶和羟脯氨酸尿水平降低）。依替膦酸在降低生物学参数方面更有效，而降钙素则产生了更快的症状缓解反应。基于这些观察结果，讨论了目前治疗佩吉特病的原则。
